Know more about Hyperuricemia
The human body resembles a machine made up of various frameworks that perform diverse and complex capacities so as to keep up inward adjust called homeostasis. When homeostasis is aggravated, a progression of framework breakdown would promptly happen, which will then prompt issue and different sicknesses. A standout amongst the most widely recognized case of body lopsidedness is hyperuricemia wherein a strangely high measure of uric corrosive aggregates in the circulatory system and framing urate precious stones amid cell turnover, or cell passing.
What is Uric Acid?
In order to trace the causes of hyperuricemia, it is important to know first what uric acid really is and how it accumulates in the blood. Uric acid is a metabolic waste product from the breakdown of purine, which is an important compound acting as a DNA or RNA nucleoside base and helps in the acceleration of many biochemical processes in the body. Due to its role in survival, purine has to be rapidly and efficiently synthesized but because the body does not have the necessary enzyme to break this down into a completely soluble material, it would be downgraded as a uric acid. It would then pass through the liver into the kidneys and excreted in the urine. So if the body acquires purine faster than it is metabolized, the higher the risk for the uric acid to accumulate.
Three Primary Reasons Behind Hyperuricemia
There are a variety of factors behind hyperuricemia such as hypertension, genetics, obesity, and diet. There are three major categories behind this abnormality: the increase of uric acid supply, lower uric acid release, and a mix of both.
The first category, the increase in production of uric acid, is often the case with people afflicted with hyperuricemia. In modern times, where fast food is the most common diet, there is a high risk of consuming purine-rich food, exceeding that of a normal range. Some of the food which contain high levels of purine are fish, organ meat, sardines, sweetbread, asparagus, and others. If this is the case, the body would definitely have a surplus of uric acid and the kidney would have a difficult time in getting rid of the large excess.
On the other hand, some genetic disorders can also cause high uric acid such as organ transplant and medical operations, a tumor lysis syndrome, cancer-afflicted person, and Lesch-nyhan syndrome since such diseases cause rapid cell turn-over and causing an even more rapid formation of urate crystals.
The second one is the decrease in the excretion of uric acid and is considered as one of the most dangerous cause of hyperuricemia since it could indicate organ malfunctioning. Medications and drugs are probably the reason behind this second category as it could suppress the action of the immune system-cyclosporine-or the activity of the kidneys-diuretics, and nicotinic acid-which would then lead to the decrease of body’s excretion of several metabolites including uric acids. Another condition, however, a ketogenic diet, or the accumulation of ketone which is toxic in large quantities, can impair the various organs like the kidneys in the proper disposal of waste products.
The third is the mix of both categories and is usually due to high consumption of alcoholic beverages and leads to both increasing production and decreasing excretion of uric acid. This could happen by the accumulation of uric acid due to the fermented ethanol and the also the decrease on uric acid excretion by the accumulation of ketone in the bloodstream.